While nitrous oxide is considered a safe and effective anxiolytic, it might not be the right choice for you. There are several risk factors or contraindications for using nitrous oxide. Tell your dentist if you have any of the following conditions:
• Currently in the first trimester of pregnancy
• A history of respiratory illnesses like chronic obstructive pulmonary disease (COPD)
• Vitamin B-12 deficiency
• A history of substance abuse
• An enzyme condition methylenetetrahydrofolate reductase deficiency
• A history of mental health conditions